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KMID : 1035520210090010009
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Brain Tumor Research and Treatment : BTRT
2021 Volume.9 No. 1 p.9 ~ p.15
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The Korean Society for Neuro-Oncology (KSNO) Guideline for Antiepileptic Drug Usage of Brain Tumor: Version 2021.1
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Moon Jang-Sup
Kim Min-Sung
Kim Young-Zoon
Hwang Ki-Hwan
Park Ji-Eun
Kim Kyung-Hwan
Cho Jin-Mo
Yoon Wan-Soo
Kim Se-Hoon
Kim Young-Il
Kim Ho-Sung
Dho Yun-Sik
Park Jae-Sung
Yoon Hong-In
Seo Young-Beom
Sung Kyoung-Su
Song Jin-Ho
Wee Chan-Woo
Lee Min-Ho
Han Myung-Hoon
Hong Je-Beom
Im Jung-Ho
Lee Se-Hoon
Chang Jong-Hee
Lim Do-Hoon
Park Chul-Kee
Lee Youn-Soo
Gwak Ho-Shin
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Abstract
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Background: To date, there has been no practical guidelines for the prescription of antiepileptic drugs (AEDs) in brain tumor patients in Korea. Thus, the Korean Society for Neuro-Oncology (KSNO), a multidisciplinary academic society, had begun preparing guidelines for AED usage in brain tumors since 2019.
Methods: The Working Group was composed of 27 multidisciplinary medical experts in Korea. References were identified through searches of PubMed, MEDLINE, EMBASE, and Cochrane CENTRAL using specific and sensitive keywords as well as combinations of the keywords.
Results: The core contents are as follows. Prophylactic AED administration is not recommended in newly diagnosed brain tumor patients without previous seizure history. When AEDs are administered during peri/postoperative period, it may be tapered off according to the following recommendations. In seizure-naive patients with no postoperative seizure, it is recommended to stop or reduce AED 1 week after surgery. In seizure-naive patients with one early postoperative seizure (<1 week after surgery), it is advisable to maintain AED for at least 3 months before tapering. In seizure-naive patients with ≥2 postoperative seizures or in patients with preoperative seizure history, it is recommended to maintain AEDs for more than 1 year. The possibility of drug interactions should be considered when selecting AEDs in brain tumor patients. Driving can be allowed in brain tumor patients when proven to be seizure-free for more than 1 year.
Conclusion: The KSNO suggests prescribing AEDs in patients with brain tumor based on the current guideline. This guideline will contribute to spreading evidence-based prescription of AEDs in brain tumor patients in Korea.
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KEYWORD
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Korean Society for Neuro-Oncology, Guideline, Brain tumors, Antiepileptic drug, Practice
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